Тип публикации: статья из журнала

Год издания: 2026

Идентификатор DOI: 10.1134/S0362119726700350

Ключевые слова: Nafld, <i>HFE</i>, triglycerides, total cholesterol, Ldl, Hdl, atherogenic index

Аннотация: Non-alcoholic fatty liver disease (NAFLD) is one of the most common chronic liver diseases. It has a complex pathogenesis, including the interaction between metabolic factors and inflammation. Iron metabolism and hereditary predictors of its changes may have a complex effect on both changes in cell metabolism as a whole and on the enhancement of inflammatory processes. The HFE protein (human homeostatic iron regulator protein, or High Fe²⁺ protein) produced by the <i>HFE</i> gene, can act as such a predictor of NAFLD. Objective—To study the relationship between biochemical markers of lipid metabolism abnormalities and <i>HFE</i> gene variants and inflammation in patients with NAFLD. The study included 52 patients with NAFLD and 72 people in the control group. Lipid profile (triglycerides (TGs), total cholesterol, LDL, HDL, atherogenic index was also calculated) were measured in both groups. The incidence of <i>HFE</i> gene polymorphisms (<i>rs</i>1800562, <i>rs</i>1800730, and <i>rs</i>1799945) was evaluated using the PCR-RT with hydrolysis DNA-probes. The Kruskal–Wallis and Mann–Whitney tests were used for statistical data processing. The prevalence of <i>HFE</i> gene polymorphisms was assessed using the χ² test with calculation of the odds ratio with a confidence interval (OR CI 95%). The <i>AT</i> and <i>TT</i> variants of <i>rs</i>1800730 polymorphism and the <i>GG</i> variant of <i>rs</i>1799945 polymorphism were more often detected in patients with NAFLD and are associated with its development. The genotype <i>AA</i> of <i>rs</i>1800730 polymorphism and the genotype <i>CC</i> of <i>rs</i>1799945 polymorphism were significantly more common among healthy volunteers. Variant <i>AT</i> is associated with increased levels of TG, total cholesterol, and HDL, while <i>TT</i> is associated with an increase in the atherogenic index, as well as an increase in the concentration of TG and total cholesterol in patients with NAFLD. The <i>GG</i> genotype is associated with high cholesterol and an increase in the atherogenic index in patients with NAFLD. The incidence of minor variants of the <i>HFE</i> gene is indicated in the development of NAFLD. The <i>rs</i>1800730 and <i>rs</i>1799945 polymorphisms are associated with dyslipidemia.

Журнал: Human Physiology

Выпуск журнала: Т.52, №1

Номера страниц: 98-104

ISSN журнала: 03621197

Место издания: Moscow

Издатель: Pleiades Publishing, Inc.

• Smirnova O. V. (Siberian Federal University)
• Lagutinskaya D. V. (Scientific Research Institute of Medical Problems of the North Division of Federal Research Center Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences)
• Kasparov E. V. (Scientific Research Institute of Medical Problems of the North Division of Federal Research Center Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences)
• Kasparova I. E. (Scientific Research Institute of Medical Problems of the North Division of Federal Research Center Krasnoyarsk Scientific Center, Siberian Branch, Russian Academy of Sciences)

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