Тип публикации: статья из журнала
Год издания: 2021
Идентификатор DOI: 10.1161/atvb.41.suppl_1.p143
Аннотация: <jats:p> <jats:bold>Background:</jats:bold> The phenomenon of the" paradox " of obesity has been studied mainly in the elderly and even senile population in the presence of one or another obvious cardiovascular pathology, usually in combination with various complications. The study in this aspect of young people (YP), taking into aПоказать полностьюccount the surrogate endpoint in the form of vascular stiffness (VS), which is the basis for assessing vascular age, has not yet been conducted. </jats:p> <jats:p> <jats:bold>Aim:</jats:bold> to study VS in relation to metabolic status in YP with increase in body mass (BM), taking into account gender. </jats:p> <jats:p> <jats:bold>Methods:</jats:bold> 93 boys and 171 girls aged 18 to 25 years were screened for risk factors (RF), including determination of total cholesterol (TC), low-density lipoproteins (LDL), high-density lipoproteins (HDL), triglycerides (TG) and glucose. Angiological screening was performed using VaSera VS-1500 (Japan). VS type CAVI was evaluated on left (L) and right (R). Three groups were formed in accordance with criteria of reduced, normal and excessive BM. </jats:p> <jats:p> <jats:bold>Results:</jats:bold> With BM increase in these groups in YM, the TC was 3,5±0,2 3,5±0,1 4±0,2 (P2-3=0.038); LDL - 1,9±0,3 2,1±0,1 2,32±0,14; TG 1,1±0,3 1,04±0,1 1,6±0,2 (P2-3=0.020); HDL 1,02±0,08; 0,99±0,04; 0,95±0,06. The girls have TC 4,02±0,2, 3,94±0,08, 4,6±0,16( P2-3=0.003; P1-3=0.033); LDL 2,1±0,2, 2,21±0,08, 2,8±0,2 (P2-3=0.006; P1-3=0.011); TG 0,7±0,04, 0,82±0,04, 1,35±0,2 (P2-3=0.000; P1-3=0.006); HDL 1,5±0,08, 1,35±0,03, 1,13±0,13 (P1-2=0.028, P2-3=0.014, P1-3=0.013). Glucose increased slightly. Against background of BM growth with such negative shifts in metabolic parameters, the CAVI, on contrary, decreased. Its gender specificity was revealed - the difference between extreme weight categories for boys was 1.4 ( P1-3=0.000) for both CAVI sides, while for girls it was only 0.3 for CAVI-R (P1-3=0.091) and 0.4 for CAVI-L (P1-3=0.053). </jats:p> <jats:p> <jats:bold>Conclusion:</jats:bold> We revealed another obesity "paradox" in form of improvement in elastic vascular status with BM increase in YP. It is also paradoxical that VS improvement takes place despite obvious deterioration of metabolic RF. Obtained results should be used when conducting preventive interventions among YP in order to control not only traditional RF, but also VS state, as another important RF. </jats:p>
Журнал: Arteriosclerosis, Thrombosis, and Vascular Biology
Выпуск журнала: Т. 41, № Suppl_1
ISSN журнала: 10795642
Издатель: Lippincott Williams & Wilkins