Тип публикации: статья из журнала
Год издания: 2023
Ключевые слова: Mucous melanoma, acral-lentiginous melanoma, KIT mutations, targeted therapy
Аннотация: Objective: The aim of the present study was to analyze mutations of the mast/stem cell growth factor receptor Kit (KIT) gene in patients with melanoma from Eastern Siberia regions of the Russian Federation. Methods: KIT gene mutations in exons 11 and 13 were analyzed by Sanger sequencing in 57 tumor samples obtained from patients wПоказать полностьюith KIT-positive melanomas localized in preferable locations. Result: Mutations were identified in 21% of patients. Among them, multiple mutations were identified in five patients. A total of 18 mutations were observed in the KIT gene, of which three were deletions and fourteen substitution mutations. Age, gender and clinicopathological characteristics of patients with cutaneous KIT-positive melanoma in Eastern Siberia corresponded to the European population. According to computational prediction tools, all mutations were evaluated as potentially harmful. Conclusion: The six novel mutations reported in the present study expand our knowledge on the molecular pathogenesis of melanoma, which can be used to further explore methods to improve disease therapeutic strategies.
Журнал: Asian Pacific Journal of Cancer Prevention
Выпуск журнала: Т. 24, № 9
Номера страниц: 3015-3020
ISSN журнала: 15137368
Издатель: Asian Pacific Organization for Cancer Prevention