Тип публикации: статья из журнала

Год издания: 2017

Идентификатор DOI: 10.1134/S1022795417080117

Ключевые слова: CAT, GPx1, GSTP1 genes, lung cancer, polymorphism of the MnSODglutathione peroxidase, 9013-66-5

Аннотация: We analyzed the polymorphic loci in the genes of the antioxidant system enzymes, such as GSTP1 (313A>G and 341C>T), MnSOD (47), GPx1 (599C>T), and CAT (–262C>>T), among 497 residents of Kemerovo oblast (Western Siberia, Russia). The analysis of the single-locus effects demonstrated a significant protective effect of the major C allПоказать полностьюele in the GPx1 (599C>T) locus. The MDR analysis of the gene-gene interactions showed that the GPx1 and the CAT genes work in close cooperation and mutually reinforce the risk of development of squamous cell lung cancer among the inhabitants of the industrial region. © 2017, Pleiades Publishing, Inc.

Журнал: Russian Journal of Genetics

Выпуск журнала: Vol. 53, Is. 8

Номера страниц: 903-909

ISSN журнала: 10227954

Издатель: Maik Nauka Publishing / Springer SBM

• Titov R.A. (Federal Research Center of Coal and Coal Chemistry, Siberian Branch, Russian Academy of Sciences, Kemerovo, Russian Federation)
• Minina V.I. (Federal Research Center of Coal and Coal Chemistry, Siberian Branch, Russian Academy of Sciences, Kemerovo, Russian Federation, Department of Genetics, Kemerovo State University, Kemerovo, Russian Federation)
• Soboleva O.A. (Federal Research Center of Coal and Coal Chemistry, Siberian Branch, Russian Academy of Sciences, Kemerovo, Russian Federation)
• Ryzhkova A.V. (Federal Research Center of Coal and Coal Chemistry, Siberian Branch, Russian Academy of Sciences, Kemerovo, Russian Federation)
• Kulemin Y.E. (Federal Research Center of Coal and Coal Chemistry, Siberian Branch, Russian Academy of Sciences, Kemerovo, Russian Federation, Department of Genetics, Kemerovo State University, Kemerovo, Russian Federation)
• Voronina E.N. (Federal Research Center of Coal and Coal Chemistry, Siberian Branch, Russian Academy of Sciences, Kemerovo, Russian Federation, Institute of Chemical Biology and Fundamental Medicine, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russian Federation)

• Scopus